Health Blog

Extreme weariness that muscular dystrophy patients suffer after soft to show possible to pertain with big action variants sildenafil (viagra), USA scientist speak, - if molecular mechanism, has newly shown on mouse can be translated on people.

Kevin Kempbell in University of the staff Iowa and colleagues studied the mouses to models Duchenne muscular dystrophy - one of the groups frustration, which cause in muscle gradually departure outside of. Kempbell studied the mouses were a weak muscle, weak, but not it is enough to to account their weariness after functioning(working).

You Search for other explanations, researchers have found that has tired the mouses comes short one of the key signal molecules in membrane their muscular hutches: neurons синтазы nitric oxide (nNOS), which causes the sprain of the blood vessels and increase кровотока to realization of the muscle. Beside sound muscles, nNOS релизы oxides of the nitrogen in the course of actions. This, in turn, draws for liberation cGMP (round-robin guanosine monophosphate), which weakens the smooth a muscle in blood vessels that brings about court to spread.

Kempbell have then shown that artificial stimulation blood vessel дилатации - by blocking the molecule деградируют that cGMP - can withstand weariness an effect. He has done this on treatment of the mouses with PDE5 inhibitor - a family drug, which includes sildenafil (viagra), which works by blocking cGMP degradations.

The Patients with the most different nervously-muscular diseases have shortened nNOS level, offerring mechanism to general weariness, which possible was pertain with inhibitor PDE5, speaks Kempbell. The Drugs such as viagra, already on the market, were designed rather short, acting so not will particularly be useful for treatment of muscular dystrophy. “We were in contact with several companies, which have done many from these preparation since their main instruction [erectile to dysfunctions], and they have that, which long action, ’speaks Kempbell. “We plan to look at some of them to hear if they are useful”.